I reproduced the problem with Galaxy, so that isn't an issue on your end, at least. Galaxy appears to be re-downloading the .Net and all of the 2012-2015 VC redistributables to a '!Temp' folder in the D:OS 2 install folder each time it verifies files.
Since a reloading fixes the problem, a save would indeed not be much help (it would at least include the state of the game world while the bug was in effect), unless you notice more of a pattern, or find a way to at least somewhat reliably reproduce the problem (ie if speaking to that NPC always or sometimes triggered the bug, rather than it being a random occurrence).
