My thought is that it doesn't take players long to decide to use their reactions while playing at a table. So, the same should be true in a video game. So, how about this for an idea:
Keep in mind this is a rough concept I just thought of, so the idea may not be perfect, but perhaps could be iterated upon into something great. What if there's a "rewind" mechanic built into the game where players have a small window of time to hit a button in real time so that they can return to the beginning of an enemy's turn before it ends? At this point, they then have to use their reaction (so that players can't keep deciding to rewind and then immediately deciding against it multiple times per round).
Once you decide to react, the game rewinds to the beginning of the enemy turn and pauses, allowing the player to decide which thing the enemy did that they wanted to react to, then allowing the player to decide how they wanted to react. This puts agency in the player's hands and doesn't interrupt the flow of combat more than once per player character per round, if that.
That sounds too complicated and unwieldy, and more importantly, it takes too much time.
