The old IE UI was beautiful but does not cut it for modern videogame standards (unless for mobile apps). Not only that, three clicks to cast a spell? the space for multiclass habs was a mess ( cleric-thieves, everyone?), etc.
I think a retro skin would be salvageable, but a game with (somewhat) complex rules needs an UI that handles lot of interact and combat options and also offers info without cover too much screen.
Given the feedback about changing the UI in DOS2, I would hope that this time round it'll be fully moddable. I have no idea whether or not this will be the case, but it'd certainly be a nice-to-have.