I am having the same issue as well. Playing on spanned Triple Screens and if I put the mouse over an item it does not target it. I have to move the mouse to right and then I can for example target an enemy. Really prevalent when using a bow. Additionally the screen will minimize arbitrarily to the taskbar. The game does not crash but this is definitely something that needs to be looked at.

Finally the game is so far amazing! Keep up the great work and looking forward to bug fixes and patches! We are all in this together!