Spoilers for entering the Gnarled Door --
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If you want to enter - I succeeded an arcana check and discovered the door is actually ephemeral, and the player can simply walk straight through it. Try clicking past it. I tried going after the hag, but my level 3 group was slaughtered by the enemies inside --
I'd hope somehow that debuff can be lifted later, or the eye grants us some great advantage later -- otherwise, it's pretty terrible if we don't want people to be reloading negative consequences! But it made some sense for my character to do it, and it'd suck to be so badly penalized for the entire game - without even a warning. I'd rather not just reload after finding out what happens. So I hold hope it can be reversed or we gain something great to offset the disadvantage! Very likely not in Act 1, however.
Edit: I just realized there's a great chance we can reverse our 'cursed' eye by simply killing the hag. Seems like reasonable thinking, anyway. I can't do it right now, so I guess we'd have to return later... but aren't we supposedly unable to return to past locations?
I got a dialogue option to basically make her hold up to the deal and heal your eye from the shadow taint since she could not fix the parasite problem. I got a magical bone to fix it, but it would not work. Bugged.