My issue may the same.
I play without issue for a while and then the game seems to freeze, catch its breath, and continue as normal. Sometimes, within that freeze it acknowledges mouse clicks so the characters sometimes end up charging into pools of fire or firing weapons randomly at points on the ground.
The issue does not appear to be fixed by lowering the graphics quality.
I'm on a PC using Windows 10 64-bit.
Intel Core i5-8600K CPU @ 3.60 GHz
16 GB RAM
NVIDIA GeForce GTX 1050