Not sure what I'd call this, bug or glitch or whatever, but I seem to have gotten my whole party locked in the room where Nettie poisons you for having an Illithid tadpole in your head. I ended up killing her for the antidote (failed my rolls), she didn't have any keys on her body and I found myself unable to unlock any of the stone slabs due to not having any thieve's tools. I've tried to cast speak with dead with Nettie's corpse but it says "Invalid Target", and after extensive searching throughout the room there seems to be no escape. Obviously I can just reload my save, but I don't think Larian intends for you to lose all progress because you are unable to escape a locked room...
TL;DR survived falling through Avernus and a crashing ship but can't defeat a few locked doors.