Ok heres another one.

Personally i think that a good fighter needs to have a wide selection of weapons...i however dont do that...i select the best and i use that untl i get a better one.

If we take a look at mages they have a wide selection of spells which would be used to counter any resistances but the point is that they do have a great selection.

Now i can understand that it would be ridiculous to suggest that certain monsters fear a certain type of weapon e.g axe...but(and this has been done with the sword in the stone quest) maybe certain quest monsters fear a special or sacred kind of weapon which would increase the offence and/or damage done to that particular monster.

ow if you didnt happen to stumble upon that particualr weapon or choose not to use it the you can still complete the quest but it will be more difficult.

To slightly expand on that idea....say a person has given you a quest and also give you say "the mace of light" and the quest is to retrieve a gem from an apparently haunted house where the master had been killed by the mace.

Now all the surrounding monsters will be effected by the mace of light but whe you se it to fight the master he will say something allong the lines of
" that bloody mace...my minions may be effected by it but i having completed my research am not".

So basically some specific monsters can be easily killed by the special weapon more easily then normal weapons....
Or wearing special armour can work as well....heping you avoid sustaining damage.