Check Larian's
Technical Support FAQ and the topic
Troubleshooting and Manual Install Procedure.
What drivers did he update? graphics, DirectX, sound? Did he install anything that runs in the background (anti-virus, etc.)?
It is possible the game (or the computer) doesn't like the new drivers, or you just might not have played it enough before the update for it to crash (depending on how frequently it crashes and how long you had played it before).
