You know, with the whole 3D-ish system and camera panning?
IMV it gets quite frustrating, especially when an enemy is high up on another level and you must pan the camera around until you can see them. Sometimes the camera doesn't "get" you want to look high up, or you don't want to look high up, or inside a building... The enemies on rooftops in the Blighted Village is an example.
Would you have preferred the game to have been FPS/third person like Skyrim?
I think this approach is awesome — it just needs a polish.
One thing that helps immensely: you can click on an enemy to focus the camera on them, and then you can target them. This isn't obvious.
