I'm having a similar issue,except it happened after I quit the game in the Blighted Town (I think that's the name of the place). After that,despite restarting my computer,updating the drivers and everything else,there's just no way for me to launch the game anymore,it always crashes during the loading screen after the initial splash screens.
One thing to note is that my computer crashed seconds after I exited the game for the last time,that might be related,though I can't say for sure
