I wrote about an experience I had in the general forum. Turns out what I did corrupts your save file and causes a crash as soon as you load anything after doing this.
The chest you can get just north of the blighted village (The one with the iron flask in part of a quest). If I take the chest, open it in my camp and then proceed to open the flask. The fight with the spectator begins. The spectator kills scratch the dog, then I kill it. If I save at any point after this event, when I load it crashes the game.
I'm unsure whether it is to do with the dead spectator or dog in camp. Or the chest. But I managed to load the game before this point fine. I did the same things again, and the saves break down after this event