The emphasis in act 1 is removing the tadpole. The emphasis in act 2 will be finding out why/who/what put them there in the first place. Maybe some of your companions are cool with just not having their skulls explode from the inside by a spaghetti of tentacles, while you and your selected group decide to figure out the what and why.
I really hope they don’t use the same twist that you have to fight your companions....post ceremorphesis or not....it was fun but not really that surprising in DoS2...Here it would just be a Larian trope. If they can write out the companions using some other plot device that makes sense, great.
What I really think that post is saying, is that all of your companions are found in Act 1, so when you leave, whomever you didn’t recruit is gone for good since there is no returning to that particular area.
Not to dwell on it too much, but I think in divinity original sin 2 it was very poorly executed, but the idea behind it was great and made sense with the narrative. here there is zero sense to it. unless we will discover there is a competition between True souls on some prize (which may be interesting and fitting with the Baldur's Gate saga, but still kinda lame after dos 2).