Ah yes do this and give more fodder for the This Ain't BG crowds mudslinging.
In all honesty (not beat the game or know why the lock happens. Don't want to know.) If it is just a mechanic to force you into a party choice then don't lock. But and it's a big butt, really big butt, if it is that it's locking out good/evil companions per the players choice. Them having followed a particular path showing their Scummy McScumbug, or Good Goldy two shoes, then by all means lock the party, it's a consequence of the choices you as the player made. Indeed even if it is based purely on the choices you as the player make then lock it. If you piss off Shadowheart and she leaves, or Le'eazel, or Gale or Whirly whoo hooo, who ever then keep the lock.
Sum it up. Don't put mechanics in any rpg game that doesn't have a purpose other then the fact you can. The whole we can do this because naaa naaa booo booo we're the devs, and you can't stop me isn't an arguement. Yet if especially with this one it makes sense, based on players actions then please put it in there.
ramble: Adding things in games that really add something like 'Us" then later removing them simply disappoints people. Have a reason for things, let players find out about them. Yes I am obsessed with Us, I enjoyed his quirky voice. It was light hearted, and humorous imo, plus he added a bit of lore to the game. Plus he was so squiiiiishy, and tentacly. Other games have 'Chosen' animal pets, blah blah blah, Ya'll had a baby intellect devourer!! that was crying for his mommy, and mommy came and you took him away from her!!!
sum it up. Add or keep mechanics that make sense. Keep Us reunite us!!