Couple of things to check here. As I had an issue at first with my desktop.
One: Check to see where your game is installed. If it is in the x86. Uninstall and move the game to the regular Program File location.
Two: Check your Video Card outside of game. Make sure all the settings use application defaults. Turn off anything that overrides application defaults.
Three: IF YOU CAN, run it on a Solid State drive.
Four: If you got it from steam, play in offline mode at first to get it to load up.
Let me know if you tried these and see where it lands you.
My game is not installed in any of both the Program File Locations but under Programs, at least that's where my Steam folder is.
My videocard should be set to default I only had this laptop for 2-3 weeks and never changed anything to it.
BG3 is installed on an SSD if I'm correct, most of my software is.
Offline mode did not make a difference for me, I've also tried resetting the Larian Launcher, but that didn;t change a thing.
Unlike OP I've had had this game running before the update of yesterday, now nothing. Keep getting CTD at start-up.
