At first I was able to play the game on ultra settings, no problem, both Vulcan and DX11. I wasn't able to play until after the 3 hotfixes, but the game ran smoothly and I was loving it. Then.... when the update came out it first filled my SSD even though it stated it was only 1,6GB and I hade 70 something GB free space. That took the whole night to solve but in the end I was able to play again and everything ran smooth. I did end up uninstalling and reinstalling the game. That was two nights ago
Last night, a new update and same disk space issue, was able to sort that out in the end but the game would crash when I clicked play in the launcher, time after time after time. Suddenly it loaded and I could play, but the game was laggy and from the task manager I could see that the game was in and out of running/not responding. Then suddenly it all worked and I got a few hours in with no issues.
Earlier today I was able to play just fine, had a dinner break and have had launcher crash when hitting play / extreme lag when the game does launch / game going in and out of running and not responding and tonight my whole computer follows the running - not responding cycle the game has. I can't play the game and when the game is up, I can't do much with my computer either. No other program is showing as not responding, only BG3, but chrome, spotify, discord, etc. all become unresponsive when BG3 is not responding (according to task manager). I've never experienced anything like this and I am no Lord of the computers, so I have no idea how to troubleshoot any further than what Mezbarrena suggested, which sadly didn't solve anything.