Those of us with a passing familiarity with D&D but not deep into it will scratch our heads and wonder what's going on, but we're not the prime audience I guess.
But fans of BG1 & BG2 are the prime audience, hence the name BG3. This would be very confusing to them.
But more importantly, even if you know nothing, BG3 itself sets up red-horned devils as monsters and enemies right at the beginning. It makes no sense to then treat them moments later like regular people. It's narrative schizophrenia.