I actually looked at 5e as more of an attempt at merging D&D with a simplified system in the style of White Wolf (Vampire The Masquerade, Werewolf Apocalypse, etc.).
WoD is unique on it's own.
Super comlex rules not required because vast majority of game is social encounters (especially for vampires)
And where rules are simplified. Game lore is INSANELY complex.
And you wouldn't really be able to "Storytell" it right, unless you learn it whole and keep most important facts in your mind.
I ran VTM games for years using a ton of the lore, while slightly modifying events and NPC's as needed to suit my needs. I do the same with 5e using decades of lore on Faerun (some of which has been retconned, so I reinterpret what would make the most sense, etc.)
I'm huge on immersion and atmosphere, and even more about getting the dice out of the way. Both systems play very similarly to me. Whereas 2nd Edition and 3rd/3.5/Pathfinder 1st Edition all made situations more about character creation from a stat stand point over anything else during my experiences.
I feel the stats aren't as important as the personality you inject in a character, so again, we're back to probably stylistic choices. But I DM more than I play as a character and I want to make it about the story, even if some of the players have NEVER played before so they can quickly get into it and feel immersed.
There's a ton of blatant, but small nods to VTM in the 5e Players Handbook too. Which is what sold me on it to start. It's literally what brought me back to D&D.
