When random NPC or PC comments are included in CRPGs I tend to turn them down to the least frequent setting. Some are inane and tiresome, and some are downright irritating ('Can I get you a ladder so you can get off my back"... <shudder>).
It is great that the companions react and stay 'alive', but if you have played and replayed a game for more hours than is entirely reasonable, the comments quickly become tedious. The worse ones are the comments that probably appear to be 'cute' or 'quirky' when first dreamed up.
I agree with Frumpkis; if the number of possible comments is low enough to be repeating more than once every, say, 1 hour of gaming time, I would prefer that the companions stayed quiet.
