As the title says...I think my biggest complaint so far is the lack of Multiclassing, even if not all the classes are available yet. I'd rather do a LVL1 Rogue / LVL3 Warlock maybe than play either class straight (mainly to get a better group of Skills for a Face who picks locks and finds traps).
The game is already extremely poorly balanced, I don't see them including multiclasses anytime soon. In older version you could multiclass or dual class for flavor but in 5e they streamlined it and reduced it to redundancy by making multiclassing always be a heavy tradeoff. They then did the incredibly intelligent thing of front loading certain classes(warlock, divination mage, war mage, swashbuckler etc) with extremely potent skills that become gamebreaking. I can demonstrate a swashbuckler multiclass that has a +20 bonus to initiative or the infamous sorlock, sorcadin or Infernal Darkness rogue build that can solo a campaign without taking damage.
I would like to see multiclassing implemented but with how poor Larian is handling balance and how poorly they have handled it before I think it is for the better that it doesn't make it into the game.