Some of the things people have mentioned were in DOS2 and I assume just aren't in yet because of EA. This still is definitely an area that Larian should strive to improve in.
Some personal thoughts:
Having multiple hotkeys for 1 skill- It didn't feel intuitive for polymorph skills and it doesn't feel intuitive for skills such as: sneak attack melee/ranged, hordebreaker melee/ranged and hordebreaker-followup melee/ranged, and upcasting spells.
Autosort for backpacks would be helpful for in combat consumable usage- Bags are currently very EA right now and will be improved, but an autosort and lock-in place feature for bags would greatly help with inventory management.
Reactions- If reactions stay as is mechanically, they will need to be able to be much more reactive. Right now I can click them multiple times, and nothing will change for an extended period of time. You need to be able to decide in a split second on if you want your reactions to be activate or not.