Also having major issues here. Didn't understand why Zarys was blowing up the room. So I cast jump on Asterion, jumped from the area before the first door to the platform next to her. One shot her with Wyvern poison and looted the room. Tried to talk to the artist but he wouldn't start a dialogue so I explore the rest of the cave... ran into Brem and his buddies. Wiped them out (including pushing Brem off a cliff into the water below). Returned to the artist and he told me to talk to Brem... but Brem's gone forever. And now, I can't save. I think it thinks I am still in a potential dialogue with Zarys. I have short rested, long rested and fast travelled around ... still can't save.