As of this writing I have only had five different play throughs on the following race/classes: Woodelf Ranger Tiefling Warlock Dwarf Cleric Drow Rogue Githyanki Fighter
During these five play throughs I always get the same option with Astarion when he asks for assistance. The first is essentially saying I can kill the creature he is talking about, while the second says something along the lines of "do it yourself."
Each option ends up with him coming at you with a knife. There are additional options that are afforded to the player based on class, stats etc, but my main complaint is that at least on my play throughs, it starts immediately with a knife and then changes.