The problem there is that the NPCs the developers decide are of one orientation might not be the ones that the players choose for their PCs.
I agree, I couldn't really understand the fuss about it until I've met Dorian, eversince I've been a "whatever floats your boat" advocate 😉
Since they are writing the romance and most of the voice acting would be the same anyway I don't really see why not.
Just meta knowing it's there won't break your game in any way (maybe make it a bit less obvious for the more sensitive among us and everybody wins).