EDIT:

Oops, my bad, at least according to 5e, it would only be on ability checks (history, insight, etc).
That being said, a FEW of these can happen in combat. If part of a spell specifically calls out them making an athletics or acrobatics check to counter it. Though spells are usually saves which (shouldnt) be effected.
There are some things like countering a shove that should be contested by the targets Athletics or Acrobatics, in which case Hex could help there.
Unfortunately it's not always clear if Larian is doing things as they are done in D&D or bending the rules behind the scene.

Last edited by Nezix; 23/10/20 10:45 PM.