I couldn't find this anywhere, and when I asked for a hint, another poster said he thought it was a bug as well, so I'm posting it here. Sorry if this is a repost.

I cannot complete the quest at Waukeen's Rest Inn. I rescued a politician and some guy that got into an argument with his wife. I took a side quest from said guy, but the place where I"m supposed to get the side quest item from isn't apparent. I *think* it's a gilded chest from the Inn, but I can't open it and I have no more lock picks. Also, when rescuing the politician, the cut scene for rescuing her plays while we're in the middle of a burning building. As we are about to walk out, she then suddenly tells me she will thank me later, even though she already sent me on a second stage for the quest.