I found out two surprising things about save scumming very early in the game (others probably found it before me, so if this isn't news to anyone, my apologies).

If you save scum the first roll in the game (the investigation check for the tadpoles pool in the nautiloid room in which you spawn), after loading the pool will almost immediately explode, and you have to be extremely quick to interact with it before that.

If you reload the game in the second room in the nautiloid (the one where you can meet "Us") a healing potion appears on the floor, which wasn't there before the reload.