I might be going out on a limb here but saying that you can create a transgender individual and it would be funny if the developers made the game recognize you as a freak miiiiiight be taken as a slightly offensive comment.

What is the problem you are solving? Does your proposed change solve the problem? Is your change feasible? What else will be affected by your change? Will your change impact revenue? Does your change align with the goals and strategies of the organizations (Larian, WotC)?