I'm a completionist, so I have to do everything in the game and I'm not a heavy roleplayer... But I started making some actual stories for my characters to justify the completionism. My Oblivion character went through all the questlines, but he started as small fry criminal (in jail for getting into a tavern fight with some unfortunate results). He was the kind of guy who's always in the wrong place at the wrong time and then has to deal with what he got himself into. I did the quests in such an order so he slowly descends into villainy as he discovers the lure of power and begins to steer his life. Cliche, but it was fun to come up with why he'd go on all the quests not particularly befitting a petty criminal who just wants The Call to leave him alone.
I typically have the same problem in these games. I have to pick up everything, and I want to know and do every little thing. It's really hard for me to fight that urge. In the Skyrim example, I could look up what content was out there and then make sure the characters I made that fit that content did it (i.e. thieves and assassin's guild stuff only for that guy, mage academy only for my mage, etc). But yeah it's rough. The containers in BG3 are my worst enemy.