[Although it's Bane's hand, Skull would be Myrkul and Bhaal]
Also, mind that the game takes place right after the events of Descent into Avernus; wherein also there are cults to the Dead Three. Now, I doubt we'll be facing a deity, or a trio directly, but something representing them? Or one that wants to tap into their power? Fits right into the series, Sarevok, Irenicus, Melissan all trying this very thing.
