Gale gives me the impression of being something of a "snake oil salesman", he tries to ingratiate himself before making his requests ("How was my deer stew? Good wasn't it? Happy you liked it... by the way do you happen to have a spare artefact I can consume? Thank you!"). He also mentions he had "dealings" with the Netherese in the past. Considering how the magic keeping the tadpole from turning you into an Illithid is Netherese shadow magic that gives me some bad vibes about Gale although it might just mean he fought the Netherese Shadovars (ancient Netherese wizard kings who escaped the cataclysm that destroyed their civilization by teleporting to Shar's real and using the shadow weave to cast their magic) in the past.
Lae'zel seems like someone who's "book smart" but doesn't really know much about the world besides what she was taught. Considering how Githyanki lie a lot to make themselves look like the best race of the multiverse I suspect she's in for a brutal awakening.
Wyll I feel will be a classical case of faustian bargain. He lies about his connection to Mizora (the glass eye). He was a nobody and was given power in exchange for his own soul. That kind of stuff rarely ends well.