The argument is academic at this point, since I don't see Larian changing the way they do things, but I will chime in.
I like some randomness to the loot, which is not to sat senseless loot. Your average goblin shouldn't have the chance to drop anything special, but for example, the Gnoll boss could be made to have a random, but equally powerful weapon, or even a piece of armor. Items can be meaningful and sensible while still being random (to a degree). Now, that would probably require some tooling around with the loot table, but not necessarily in a very demanding way.
Hypothetically (and ideally, of course), for those of you who like the loot to remain the same, if the game gave us the option for new maps, dungeons, story, etc. for each playthrough, would you take it, or would you replay the same story again to capitalize on knowing what is coming? I certainly would want the former, but I know that is just not logistically feasible in its entirety. But I see 'random loot' as one small step towards capturing that option.