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I'd like a random aspect ; and if people don't get the loot they need they can barter with a trader for something.
You mean S/L until you get what u want?
I believe it can be done without allowing S/L to change anything. Seed the items at first entry to an area. S/L would still contain the same items but replay would vary the items a bit. The drops should be the same caliber but vary to some degree.