I find despite being "high" attitude with Astarion and only medium with Shadowheart and neutral with Lae'zel, the game still prioritizes their interactions.
Yeah, I was amazed at all the new interactions I got with Astarion when I did a Lone Wolf run (I recruited Gale too but he stayed in camp permanently).
I also dislike that so many meaningful interactions are gated behind abusing the tadpole. Though that does make it more tempting.