I'm reading the replies and I just want to thank you all for weighing in on this.
I'm definitely going to check out turning off screen-shaking, but that's kind of a shame to turn it off just for Eldritch Blast. In other instances, it's probably fine.
I'll also be trying to use the O key more often. I find the isometric view preferable most of the time, but maybe I should switch to Overhead for a bunch of combats to test it out.
CMF,
I am mostly ok with target snapping, but it's not great in conjunction with AoE spells, and certain throwable objects.
In regards to targets moving away from my cursor, I am mostly speaking to ranged attacks using a bow or crossbow. These have a different feel to them than spells.
An easy way to replicate my frustration would be to take a couple of Archers (Your PC + Lae'zel with a Bow) into the control room of the Nautiloid ship, hide behind some obstacles like maybe 6 Nautiloid Tanks that you collected, and try and kill the three demons there using only arrows. You will notice that the tanks create an impediment not only to the path of the cambions, who get stuck behind them (keeping you safe for this test), but also to the path of your arrow attacks.
Every time you want to attack in this instance, you must be cautious in dragging the cursor over only certain parts of the Cambion, because A) the Cambion is moving due to its animation and B) if you miss, you may accidentally hit one of the tanks you placed. Switching to the overhead view might work, but I would still be pretty afraid of accidentally hitting one of the tanks because overhead view gives you less control over the vertical arc of your arrows since you can only pan horizontally in this view.