It's easy to get carried away and just pick up every item you come across, but after some time I learned to just mentally block out all the loot able items that were unlikely to be used for anything but decoration. I feel it does add some liveliness to the room though, at least when compared to other games' generic static backgrounds that you can't interact with.
That being said I do wish the game would tell you if a container such as a crate was empty before you opened it.
This. Would also like to loot groups of containers rather than every one.
