One thought about labeling thing as trash:
In Numenera many items were labelled as useless (called oddeties) so at least I did not look at them and just sold them.
PST had some items where you do not know what they are good for and some of them are used for quests, e.g. modron cube.
PST was the better game, among other reasons because you had to find out many things yourself.
The gem for the twisted rune in BG2 may be another example.
But it makes a difference if we talk about games with relatively few items and the use of some of them is not clear which could make you miss a side quest
OR if we talk about games that are littered with tons of useless items. Collecting 1000 spoons and glasses and selling them is not really fun.

Prof. Dr. Dr. Mad S. Tist

World leading expert of artificial stupidity.
Because there are too many people who work on artificial intelligence already