You have Enchant Weapon and are clicking on an equipped item with a Charm Quality?
The charm pane is likely opening off screen. Run the configuration program and increase the resolution, start the game, open a charm pane, move it into the center of the screen and close it. Quit, run the configuration program again and restore the original resolution; now when you re-start, they should open on screen.
If you are already playing at 1024x768, you can edit the config.div file to play at a higher resolution, such as 1280x1024.
