Just for trouble shooting and "what if's"...
Try to change the display mode to/from full screen or false windowed mode. Ensure there isn't any confirmation prompt in the background, also try a different render mode between DX11 or Vulkan.
Does anything work at all when in game? Press C to sneak, I for inventory, or try casting spells/attacking (is it taking any mouse input at all? or is it only movement that isn't being registered).
Have you tried making another character to see if that happens again? Is your character encumbered somehow?
Is this on a mac or pc or an emulation from a linux?
Basically, what is possibly different in your situation that could be changed?
