Yeah I get what you're saying too. I agree that Larian shouldn't be expected to balance the game for every possible combination of options. And the game would strictly be better if Larian added all these toggles (at the very least it would make it easier for modders to make X-set of toggles a balanced game).
I just want some of these toggles (e.g., 3 short rests with less emphasis on frequent long rests) to be the default options Larian balances the game around. Then add toggles to allow more rests.
