More hotbar customisation is definitely needed. I'd also greatly prefer if upcasting was condensed in pretty much any way that won't make the spells take up individual hotbar slots.
Many other CRPGs already have perfectly functional UIs that can handle characters with very large amounts of spells, and I heavily implore Larian to allow themselves to be inspired by these games. Having to cycle hotbars in DOS2 really wasn't fun and I hope it won't become another necessity in BG3.
Personally I think I'd prefer if I could choose to display one more row of ability slots at the bottom of my screen, but I won't be picky. I'll take any feature or implementation that makes me able to have more abilities and items slotted.