I'm hoping there will be an "iron-Man" mode that combines more "realistic" stuff too, like limited overnight camping in dungeons where you need to set a guard and carry food/wood/tinderboxes and blankets around.
These are the sorts of things, along with some more difficult aspects like mobs using everything players do, and the fixing of some broken spell/class things that seem like they are currently just unfinished bits that will eventually come about, that I'd very much enjoy seeing implemented into the game.