Many people are tossing in +1's. I'd like to hop on-board, and toss in a -8,589,934,592.
This is a completely impractical idea. It only seems like a good idea to people who don't know anything at all about programming.
You have listed 33 options, each of which has two states, "on" or "off". That is 2 to the power of 33 combinations, or 8,589,934,592 possible combinations. Do you think that there somehow won't be glitches and bugs, locks and crashes with certain combinations of those 8.6 BILLION combinations? That's not likely. Diagnosing bugs created in a game with that system will be impossible. The QA department would quit en masse.
It would also be completely throwing balance out the window, because there will be certain combinations which are balance-breaking - for good and for bad. There would be no way for Larian to even decide what toggles are on and off, never mind for different difficulty levels. This would be giving up on the idea of balance completely and telling players "do whatever, change some toggles if you don't like it".
The fact is, no matter how many options get added, Larian is not going to be able to test the entire game with more than like, 10 combinations. They are going to need to make the default balance around specific settings anyway, and test to those. Which means when players play with different settings among the 8.6 BILLION than what Larian uses, they will inevitably hit some encounters which are too easy with those settings, or too hard with those settings, and then they'll complain about bad balance.
Too many cooks spoils the broth. Too many options breaks the game.
100% WRONG
Obviously you don't have have a clue about programming.
The game as is is totally unbalanced and simply broken in a lot of ways right now, putting in more options for customising your game is only a positive and won't take anything away from anyone.
Look at the Long war mod for X-com that was made by modders and it singlehandeldly made the game many times better. if Larian can't handle to put in a single switch for different options they shouldn't be making videogames.
If by your flawed logic turning stuff on/off will spin out of contol like you suggest, why do we then have options for putting all the different items we pick up on the hotbar or not? , theres 29 options turn turn things on/off allready in the gameplay options menu, by your logic that is an impossible task.