I'm sorry to hear that. I've had that problem too. Moving with WASD is a good suggestion. In the meantime, you might also try a controller, if you like. That solved the finger strain problem for me. (The game's controller support is excellent.)
Nice to know that others have been going through the very same thing with aching fingers from the game. Thanks for the controller recommendation and letting me know that DOS:2 does have good controller support, I've been on the fence about that because there's things like skills on your hotbars which might be a pain to go through with a controller so this is reassuring to hear.