Roughly 10% of the population has colorblindness of one type or another. BG3 supposedly sold over a million copies on Steam which means potentially 100,000+ players that are trying to play the game colorblind.
I'm sure there are probably other things I haven't noticed(cause I can't tell that something is suppose to be different) but here are at least 2 slight changes that would be easy fixes for 2 things I have noticed.

Spell slots: Personally I can not tell which slots are still active and which are spent unless I mouse over a spell icon and see which slot starts flashing. Simple fix would be to "X" out spent spell slots rather than color them differently.

Minimap icons: The minimap icons for Friendly/Neutral/Enemy are all diamond shapes with different colored centers. Once again I can not tell which color is which so all 3 are just diamonds to me. I suggest changing the shape of 2 of those. Leave Friendly as a diamond, make Neutral a triangle(yield sign) and Enemy a octagon(stop sign) or maybe an "X" or some such.

Any other colorblind players notice things that could be slightly tweaked to make things easier for us to play the game?