I think Larian is going to pull an Obsidian and basically create a Mask of the Betrayer type of story.
Basically the Dead Three come up with the idea of the Absolute, which is a Mask of ultimate authority that they all give their power to and then spread the religion as far and wide as possible to increase it's power and then they share it equally (lol) which will obviously not work out because they are all scheming bastards. They ultimately want to become the Absolute One, who is actually Three (where have I heard this before?) which obviously pisses off all other deities because that would infringe upon their domain.
Good deities will simply oppose them face to face, while evil deities instead will try to subvert them so that they can take hold of the Mask that is the "Absolute" so they can grab a huge chunk of power for themselves.
Shar and Lolth will both be meddling because they have much to lose if they simply let the other one do their own thing and sitting back (Lolth hates Shar's guts now because Shar took over the portfolio of caverns and the underdark, and Shar naturally expects Lolth to meddle, so she will try to cross her). Cyric is out of the picture because he is in prison. Kelemvor probably has an interest in keeping the dead three in check because they have portfolios closely related to his own. Vlaakith is still not a deity and maybe she hopes to become one.

Basically I think that by the end of the story we will decide who gets to be the absolute. We will be Godmakers (kinda like in PoE).

I expect to be courted by several high level deities. Maybe Jergal wants his powers back?
At any rate the story seems to be about a civil war amongst the evil deities for the most part.