In general? Depends on the game.

In this game? Hard to tell until it's playable, but I loved it in DOS:2. From what I've seen datamined this game will be even better, so I'd be surprised if I didn't.

That said, I always do a couple of runs on a custom character first, then do Origin runs to 'get to know' the character details I missed in the custom runs. Definitely adds replayability.