This issue occurred after the most recent update. For whatever reason the game will just straight up crash when I'm talking to an NPC. It appears to be somewhat random and it usually takes me getting past the first few sets of dialog choices. I'm also seeing about a 50/50 chance of it crashing when I make skill checks while talking to NPC's. I updated my GPU drivers, Chipset, etc and have tried both Vulcan and DX 11. Did a restart of my system and a fresh driver install as well. Kept seeing a 0xfffffc01 error in event viewer so I ran SFC and made sure windows was up to date. None of this resolved the issue. I will continue to investigate when I have more time.
The route cause appears to have been the 0xfffffc01 error I'm see in event viewer. Here is how I fixed it:
Press Windows key + R
Type:
C:\Windows\system32\config\systemprofile\AppData\Local\
Hit Enter
Create the folder TileDataLayer
Open it then create another folder called Database
Source:
Microsoft Forums