I hope domain selection is limited by deity selection.
Alignment is gone, so your deity is the only thing that could restrict you.
- NWN2 had no restrictions at all, deity selection did nothing and players could select domains as they like it. So you could have an evil cleric of the god of death with the life domain (you are still the heal bot for the party) and the water domain (because you want to have evasion)
- Pathfinder kingmaker limits domains, deities and alignment, but the selection is so large that players will rarely have a problem to find gods and domains that fir their character.
I like this more. A cleric from the god of darkness with the light domain makes no sense. DnD 5E has tons of gods and domains, so every player should be able to find something that fits.

Prof. Dr. Dr. Mad S. Tist

World leading expert of artificial stupidity.
Because there are too many people who work on artificial intelligence already