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For main storyline there is nothing important ...
For sidequest with necro-book ... there is gem that opens it, but that book seem unfinished anyway, so all you get from it is consumable artefact for Gale, and speak with dead spell if you roll your dice right.
And there is actualy quite interesting loot ... specificly cloth chest that will add 1-4Dmg for all your poison spells.
Then some gold, some xp, and boots that allow you walk on webs ... that is about all, if im not mistaken.